Mexicali's location provides excellent access to US I-8 and I-10. Roads through the city are wide and access to the 20 industrial areas is adequate. Truck rates vary from $1.20 - $2.00 US per mile and are negotiable. Regular freight and container rates are comparable to the border cities. There is a rail link from Tijuana and to other Mexican and US cities. Rail access is provided by Pacific railroad on the U.S. side and Chihuahua Pacific Railroad and the National Railway Network on the Mexican side. Rates are published, spurs to several industrial parks are available. Water, electricity, and gas are available throughout the city. A water treatment plant recently underwent a large expansion of its capacities.

Mexicali has two ports of entry. The original crossing in Mexicali links to U.S. Hwy 111. The new commercial crossing is approximately 8 miles east of the original crossing. Mexicali's industrial growth follows the border crossings and has resulted in new industrial and residential areas.

Air transportation is provided by Mexicali's International Airport (12 miles east from the city) and the regional Imperial Valley Airport (15 miles north of the border with the U.S.).

Baja is considered a Free Trade Zone by the Mexican government, a designation roughly similar to a US Foreign Trade Zone. Maquilas pay Mexicali City taxes and BCN. State taxes are roughly 4% additional of the base wage paid per worker.